US
Proferrin

Proferrin ES Heme Iron Polypeptide Tablets

  • 10.5 mg heme iron polypeptide per tablet
  • 90 tablets, unflavored
  • Gentle on the gut, per the title
  • Made in the USA, gluten free
  • Iron support is the listed benefit

Last refreshed Aug 4, 2026 · Based on the Amazon listing and published specifications, not hands-on testing.

Our verdict

A heme iron tablet aimed at people who find ordinary iron hard on the stomach. The title makes claims about coffee and calcium that the listing does not explain further.

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ASIN: B00MJPVZC6Category: Iron Supplements

Overview

Not a plain iron salt, this supplement uses heme iron polypeptide, the form the product name describes as high absorbing. It comes as an unflavored tablet made in the USA.

The reason to consider it is the heme form, which the title says is easy on the gut and not affected by coffee, calcium or acid reducers. The limit is that all of that comes from title text, with no bullets or full ingredient panel to back it up.

Who it's for

A person managing iron support under a doctor's guidance, who also drinks coffee or takes calcium or stomach acid medicine, may find the title claims relevant. Look elsewhere if a vegan label or a chewable format matters.

Pros and cons

Pros
  • Heme iron polypeptide form
  • Easy on the gut, per title
  • Made in the USA
Cons
  • Carries no vegan label
  • Serving size not listed
  • Claims come from the title only

Performance notes

Heme iron is taken up by a different route than non-heme iron salts, which is why the title says coffee, calcium and acid reducing drugs do not interfere. The amount absorbed still varies by person, and iron should be used under a clinician's advice.

Specifications

BrandProferrin
Supplement TypeIron (heme iron polypeptide)
FormTablet
DietGluten free
Count90 tablets
FlavorUnflavored
BenefitsIron support
Iron per tablet10.5 mg

Frequently asked questions

What comes in a bottle of Proferrin ES?

One bottle of 90 unflavored tablets. The listing shows no extra items.

Does Proferrin ES contain gluten?

The diet and allergen fields both list gluten free.

Is Proferrin ES a vegan iron?

No claim of that kind appears. Heme iron polypeptide is the active form, and the listing gives no vegan label.