Vetoquinol Zylkene - Calming Oral Capsule for Small Cats & Dogs 11-22 lb - For Behavior &…
- Calming Aid
- 1
- 30
- 424083
- More reviewed than 78%
A milk-protein calming capsule sized for small dogs and cats, useful for short-term situational stress rather than ongoing behavioral treatment.
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How it ranks among the 63 calming aids we track
4.1★ across 3,660 Amazon ratings, Bayesian-smoothed toward the category average.
3,660 Amazon ratings, weighted on a log scale so huge counts don't drown everything.
2,000+ bought on Amazon last month.
Brand identity, imagery, description and spec coverage.
The ProductDome score is separate from the Amazon rating shown above: it combines the Bayesian-smoothed Amazon rating with evidence volume, tracked demand, and data quality across the 63 calming aids we track - how the scorecard works · full calming aids data report. Confidence: medium - useful but incomplete evidence.Last refreshed Aug 4, 2026. Data-computed, not a hands-on test. Compiled by the ProductDome Research Team.
Overview
Zylkene is an oral capsule built around alpha-casozepine, a compound derived from hydrolyzed bovine milk protein, dosed at 75 mg per capsule for dogs and cats in the 11 to 22 lb range. It is marketed for situational stress rather than daily sedation.
The active ingredient here is a milk-derived peptide, not a drug in the sedative sense, which is why Vetoquinol positions it as non-drowsy. That distinction matters for owners who want a dog alert during a vet visit or move, not knocked out. It is lactose-free despite the milk origin, since the processing isolates the protein fraction.
- 75 mg alpha-casozepine per capsule
- Derived from hydrolyzed bovine milk protein
- 30 capsules per package
- Formulated for dogs and cats 11-22 lb
Who it's for
Owners managing predictable stress events, boarding, travel, fireworks, or vet trips, for a small dog or cat between 11 and 22 lb. It is not framed as a treatment for chronic or severe anxiety disorders.
Strengths and trade-offs
Drawn from this product's published specifications.
- Non-drowsy formula for situational stress
- Lactose-free despite milk protein source
- Sized specifically for small dogs and cats
- Only fits the 11-22 lb weight range
- Not intended for severe or chronic anxiety
Performance notes
Alpha-casozepine works by binding to GABA receptors similarly to how the compound behaves in nursing infants after milk consumption, producing a calming effect without the grogginess associated with sedatives. Effects are generally described as gradual rather than immediate, so timing a dose well ahead of the stressful event matters more than with a fast-acting drug.
Specifications
| Brand | Vetoquinol |
|---|---|
| Model | 424083 |
| Dimensions & fit | |
| Dog Breed Size | Small |
| Included components | |
| Unit Count | 30 |
| Other details | |
| Number Of Items | 1 |
| Best Sellers Rank | #2,654 in Pet Supplies (See Top 100 in Pet Supplies) #33 in Dog Relaxants |
| Product Benefits | Anxiety Relief,Promote Relaxation,Reduce Stress |
| Active Ingredients | Active Ingredients: Hydrolyzed Milk Protein (Bovine): 75 mg (providing alpha-casozepine) |
| Model Number | 424083 |
| Flavor | Milk |
| Manufacturer Part Number | 424083 |
| Asin | B07S5KTWLQ |
| Item Form | Capsule |
| Manufacturer | Vetoquinol |
| Specific Uses For Product | anxiety, moving, stress, thunderstorms |
| Customer Reviews | {'ratings_count': '3,660', 'stars': '4.1'} |
| Target Species | Dog |
Other Vetoquinol calming aids
How it compares
This product against the closest alternatives we track in calming aids.
| Product | Amazon rating | Ratings | ProductDome score |
|---|---|---|---|
| Vetoquinol Zylkene - Calming Oral Capsule for Small Cats & Dogs 11-22 lb - For Behavior &…This product | 4.1 / 5 | 3,660 | 4.1 / 5 |
| ThunderShirt for DogsThunderShirt | 4.2 / 5 | 55,700 | 4.3 / 5 |
| Rescue Remedy Pet DropperRescue | 4.2 / 5 | 19,500 | 4.3 / 5 |
| Advanced Calming Chews for DogsAdvanced | 4.4 / 5 | 2,500 | 4.4 / 5 |
| Zesty Paws Calming Chews for Dogs Composure & Relaxation for Everyday Stress & Separation…Zesty | 4.1 / 5 | 26,600 | 4.3 / 5 |
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Questions about the Vetoquinol 424083
Common buyer questions answered straight from the product spec data - no fluff, no "it depends".
Will Zylkene make my dog drowsy?
No, it is formulated as non-drowsy, working through a milk-derived compound rather than a sedative.
Can cats take Vetoquinol Zylkene?
Yes, this size is labeled for small cats and dogs between 11 and 22 lb.
Is this safe for dogs with lactose sensitivity?
The capsule is lactose-free even though the active ingredient comes from milk protein.