Liver Health Supplement for Large Dogs
- Herbal Supplement
- 30
- 1
- 2 years
- More reviewed than 62%
Worth a look if you want a SAMe and milk thistle combination targeted at liver support in a large dog, rather than a general multivitamin.
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How it ranks among the 42 herbal supplements we track
4.4★ across 483 Amazon ratings, Bayesian-smoothed toward the category average.
483 Amazon ratings, weighted on a log scale so huge counts don't drown everything.
800+ bought on Amazon last month.
Brand identity, imagery, description and spec coverage.
The ProductDome score is separate from the Amazon rating shown above: it combines the Bayesian-smoothed Amazon rating with evidence volume, tracked demand, and data quality across the 42 herbal supplements we track - how the scorecard works · full herbal supplements data report. Confidence: high - strong rating volume and complete data.Last refreshed Aug 4, 2026. Data-computed, not a hands-on test. Compiled by the ProductDome Research Team.
Overview
A 30-tablet liver support supplement labeled for large dogs, combining 425 mg of SAMe with 35 mg of Silybin A+B from milk thistle, formulated free of crustacean, egg, gluten and nut allergens.
This pairs two ingredients, SAMe and milk thistle derived Silybin, that are commonly used together in liver support supplements. The listing does not include a per-dog dosing schedule, so that would need to come from a vet.
- 425 mg SAMe per tablet
- 35 mg Silybin A+B from milk thistle
- 30 tablets per bottle
- Allergen free formulation
Who it's for
Aimed at large breed dogs where a vet or owner is targeting liver support. Not labeled for small or medium dogs, and no dosing chart is included with the listing.
Strengths and trade-offs
Drawn from this product's published specifications.
- SAMe plus milk thistle Silybin combination
- Free of crustacean, egg, gluten and nut allergens
- 2 year manufacturer warranty
- Labeled for large dogs only
- No dosing schedule listed in the specs
Performance notes
Each tablet combines SAMe with Silybin A+B extracted from milk thistle, two ingredients commonly paired in liver support supplements, though the listing does not specify a per-dog dosing schedule.
Specifications
| Brand | Liver |
|---|---|
| Model | SA004 |
| Dimensions & fit | |
| Dog Breed Size | Large |
| Included components | |
| Unit Count | 30 |
| Included Components | S-Adenosylmethionine, SAMe, Silybin A+B, Milk Thistle, Silymarin |
| Warranty & support | |
| Warranty Description | 2 years |
| Other details | |
| Number Of Items | 1 |
| Manufacturer Part Number | SA004 |
| Allergen Information | Crustacean Free, Egg Free, Gluten Free, Non-GMO, Nut Free |
| Asin | B09YMTS54V |
| Item Type Name | Liver Tablets |
| Manufacturer | Vet Perfect Inc |
| Best Sellers Rank | #6,118 in Pet Supplies (See Top 100 in Pet Supplies) #26 in Dog Herbal Supplements |
| Product Benefits | Heals liver illness and inflammation. Eliminates toxins and harmful chemicals. Enhances cognitive brain functions. |
| Customer Reviews | {'ratings_count': '483', 'stars': '4.4'} |
| Active Ingredients | S-adenosylmethionine (SAMe) 425 mg, Silybin A+B 35 mg (from 125 mg of Milk Thistle) |
| Item Form | Tablet |
| Model Number | SA004 |
| Target Species | Dog |
| Flavor | Other |
| Specific Uses For Product | Behavior, Stomach, Urinary |
How it compares
This product against the closest alternatives we track in herbal supplements.
| Product | Amazon rating | Ratings | ProductDome score |
|---|---|---|---|
| Liver Health Supplement for Large DogsThis product | 4.4 / 5 | 483 | 4.1 / 5 |
| Pet Wellbeing Milk Thistle for DogsPet | 4.6 / 5 | 2,334 | 4.3 / 5 |
| Native Pet Dog UTI TreatmentNative | 4.4 / 5 | 2,045 | 4.2 / 5 |
| Amber NaturalZ Vibactra Plus Herbal Supplement for DogsAmber | 4.6 / 5 | 1,400 | 4.2 / 5 |
| Cat & Dog UTI Treatment & Urinary Tract Infection Remedy with Cranberry & D-MannoseCat | 4.4 / 5 | 1,328 | 4.2 / 5 |
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Questions about the Liver SA004
Common buyer questions answered straight from the product spec data - no fluff, no "it depends".
What is in the SilymarinAdvanced SA004 liver tablets?
Each tablet combines 425 mg of SAMe with 35 mg of Silybin A+B from milk thistle.
Is this liver supplement suitable for small dogs?
The listing specifically targets large breed dogs.
How many tablets are in a bottle of SA004?
The bottle contains 30 tablets.