Differin Acne Treatment Gel
- Gel
- Dry, Sensitive
- Tube
- 3.2 ounces
- More reviewed than 99%
A long-supply adapalene retinoid gel built for ongoing acne treatment, worth it for the two-tube 180-day quantity if adapalene already suits your skin.
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How it ranks among the 238 gels we track
4.5★ across 71,000 Amazon ratings, Bayesian-smoothed toward the category average.
71,000 Amazon ratings, weighted on a log scale so huge counts don't drown everything.
180+ bought on Amazon last month.
Brand identity, imagery, description and spec coverage.
The ProductDome score is separate from the Amazon rating shown above: it combines the Bayesian-smoothed Amazon rating with evidence volume, tracked demand, and data quality across the 238 gels we track - how the scorecard works · full gels data report. Confidence: high - strong rating volume and complete data.Last refreshed Aug 4, 2026. Data-computed, not a hands-on test. Compiled by the ProductDome Research Team.
Overview
A two-tube pack of Differin's 0.1% adapalene retinoid gel, sold as a 180-day supply for acne-prone, sensitive skin. Each tube holds 45g, and the formula is fragrance-free.
Adapalene is a retinoid, an active ingredient class rather than a moisturizer, so this product is applied to treat acne over time rather than to hydrate. The 180-day framing reflects a once-daily, thin-layer use pattern typical of retinoid gels rather than a heavier daily-use cream.
- Two 45g tubes, 180-day supply total
- 0.1% adapalene retinoid gel
- Fragrance-free, made by Galderma
- Formulated for acne-prone, sensitive skin
Who it's for
Suits people managing acne who want an adapalene-based retinoid rather than a benzoyl peroxide or salicylic acid product. Not the right pick for anyone without active acne concerns, or for skin that can't tolerate retinoid irritation.
Strengths and trade-offs
Drawn from this product's published specifications.
- 0.1% adapalene, a clinically recognized retinoid strength
- Two tubes covering a 180-day supply
- Fragrance-free formulation for sensitive, acne-prone skin
- Retinoids commonly cause initial dryness or irritation
- Results build over weeks rather than immediately
Performance notes
Adapalene works over weeks of consistent use rather than as a quick fix, consistent with the product being sold as a 180-day supply across two tubes instead of a single small tube. Being fragrance-free matters here since retinoids already carry a higher irritation risk, and added fragrance would compound that for sensitive skin.
Specifications
| Brand | Differin |
|---|---|
| Model | 0299.492045 |
| Construction & materials | |
| Material Features | Fragrance Free |
| Included components | |
| Unit Count | 3.2 ounces |
| Other details | |
| Skin Type | Dry, Sensitive |
| Container Type | Tube |
| Asin | B07H5WQQL7 |
| Special Ingredients | adapalene |
| Customer Reviews | {'ratings_count': '71,096', 'stars': '4.5'} |
| Model Number | 0299.492045 |
| Item Form | Gel |
| Upc | 302990332995 |
| Active Ingredients | Adapalene 0.1% |
| Item Type Name | Retinoid |
| Manufacturer | Galderma |
| Scent Name | Unscented |
| Product Benefits | Anti-Acne |
| Manufacturer Part Number | GP-BUTTY24426 |
| Set Name | Differin Acne Treatment Gel, 180 Day Supply, Pack of 2 |
| Target Use Body Part | Face |
Other Differin gels
How it compares
This product against the closest alternatives we track in gels.
| Product | Amazon rating | Ratings | ProductDome score |
|---|---|---|---|
| Differin Acne Treatment GelThis product | 4.5 / 5 | 71,000 | 4.4 / 5 |
| Simple Kind to Skin Refreshing Facial Wash GelBrand | 4.6 / 5 | 28,500 | 4.6 / 5 |
| patanjali Aloe Vera Gelpatanjali | 4.4 / 5 | 7,300 | 4.5 / 5 |
| Bioderma Sensibio Foaming Gel Gentle Face CleanserBioderma | 4.7 / 5 | 22,700 | 4.3 / 5 |
| Nature Republic Mild & Moisture Aloe Vera Watery GelNature Republic | 4.6 / 5 | 13,200 | 4.1 / 5 |
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Questions about the Differin 0299.492045
Common buyer questions answered straight from the product spec data - no fluff, no "it depends".
What is the active ingredient in Differin Acne Treatment Gel?
Adapalene at 0.1% concentration, a retinoid.
How long does this pack last?
It's sold as a 180-day supply across two 45g tubes.
Is Differin gel fragrance-free?
Yes, the listing specifies a fragrance-free formula.